Progression of antiphospholipid antibody syndrome to catastrophic antiphospholipid antibody syndrome acutely with cessation of antithrombotic therapy
Identifieur interne : 001358 ( Main/Exploration ); précédent : 001357; suivant : 001359Progression of antiphospholipid antibody syndrome to catastrophic antiphospholipid antibody syndrome acutely with cessation of antithrombotic therapy
Auteurs : V. S. Katikireddi [Australie] ; D. A. Kandiah [Australie]Source :
- Internal Medicine Journal [ 1444-0903 ] ; 2012-05.
English descriptors
- Teeft :
- Adrenal glands, Antibiotic exposure, Anticoagulation, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid antibody syndrome, Antiphospholipid syndrome, Antithrombotic therapy, Aptt, Arthritis rheum, Australasian, Brief communication, Cardiogenic shock, Catastrophic antiphospholipid antibody syndrome, Catastrophic antiphospholipid syndrome, Cessation, Chest pain, Chronic thromboembolic, Clostridium infection, Connective tissue disorder, Devastating consequences, Diagnostic criteria, Disease severity, Dysfunctional uterine, Embolus, Expert opinion, Hormonal therapy, Hospitalised patients, Intensive care, Intensive care medicine, International consensus statement, Lupus, Lupus anticoagulant, Medicine journal, Menorrhagia, Multiorgan failure, Myocardial infarction, Partial thromboplastin time, Platelet, Pleuritic chest pain, Positive apls, Positive drvvt ratio, Probable caps, Prophylactic therapies, Pulmonary embolus, Recurrent thrombosis, Right heart failure, Risk factor, Risk factors, Royal australasian college, Royal perth hospital, Screening tests, Syndrome, Systems tissues, Thromb haemost, Thromboembolic, Thromboses, Thrombosis, Tract infection, Transthoracic echo, Venous, Ventilation perfusion scan, Ventricular ejection fraction, Warfarin, Warfarin therapy, Western australia.
Abstract
Catastrophic antiphospholipid antibody syndrome (CAPS) is a serious condition that is often unrecognised with a high mortality. Cessation of anticoagulation in antiphospholipid antibody syndrome (APS) can have devastating consequences with progression to CAPS. Making a diagnosis of APS can however be challenging because of the evolving diagnostic criteria and difficulty in confirming thromboses. Management of these patients can also be complex, especially in those with coexistent thrombocytopenia. New potential treatments are emerging targeted on the immunomodulation of APS rather than just prevention of thrombosis. This article aims to highlight these diagnostic and management difficulties by reporting and discussing three cases of APS with progression to CAPS following cessation of anticoagulation, one with fatal consequences, with confirmation of CAPS on autopsy, and two with successful treatment and outcomes.
Url:
DOI: 10.1111/j.1445-5994.2012.02768.x
Affiliations:
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Cessation of anticoagulation in antiphospholipid antibody syndrome (APS) can have devastating consequences with progression to CAPS. Making a diagnosis of APS can however be challenging because of the evolving diagnostic criteria and difficulty in confirming thromboses. Management of these patients can also be complex, especially in those with coexistent thrombocytopenia. New potential treatments are emerging targeted on the immunomodulation of APS rather than just prevention of thrombosis. This article aims to highlight these diagnostic and management difficulties by reporting and discussing three cases of APS with progression to CAPS following cessation of anticoagulation, one with fatal consequences, with confirmation of CAPS on autopsy, and two with successful treatment and outcomes.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Queensland</li></region></list><tree><country name="Australie"><region name="Queensland"><name sortKey="Katikireddi, V S" sort="Katikireddi, V S" uniqKey="Katikireddi V" first="V. S." last="Katikireddi">V. S. Katikireddi</name></region><name sortKey="Kandiah, D A" sort="Kandiah, D A" uniqKey="Kandiah D" first="D. A." last="Kandiah">D. A. Kandiah</name><name sortKey="Kandiah, D A" sort="Kandiah, D A" uniqKey="Kandiah D" first="D. A." last="Kandiah">D. A. Kandiah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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